Effects of natural polysaccharide addition on drug release from calcium-induced alginate gel beads.
نویسندگان
چکیده
Calcium-induced alginate gel beads (Alg-Ca) containing various polysaccharides, including an alginate hydrolysate, were prepared and the drug release profiles were investigated. Hydrocortisone (HC) was gradually released from Alg-Ca into the mimic gastric fluid, while in intestinal fluid, it was quickly released with the dissolution of Alg-Ca. However, with Alg-Ca containing 5% chitin (CT), dissolution of Alg-Ca was not observed, and release of HC showed apparent zero-order kinetics. Furthermore, addition of the alginate hydrolysate altered the HC-release profile for Alg-Ca.
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 51 2 شماره
صفحات -
تاریخ انتشار 2003